
Buescher fastest in Happy Hour: #1-James Buescher was quickest during the final practice session at Daytona with a speed of 184.087mph. He was followed by: #15-Michael Annett, #24-Eric McClure, #98-Paul Menard, #7-Danica Patrick, #38-Kasey Kahne, #62-Brendan Gaughan, #22-Brad Keselowski, #88-Dale Earnhardt, Jr., and #10-Jason Leffler. Just 51 drivers practiced during the session. #04-Brad Teague spun after cutting a tire down, but did not hit anything.(2-11-2010)
| Pos | Car | Driver | Team | Time | Speed | # Laps |
| 1 | 1 | James Buescher # | Phoenix Racing Chevy | 48.890 | 184.087 | 7 |
| 2 | 15 | Michael Annett | Pilot Travel Centers Toyota | 49.045 | 183.505 | 17 |
| 3 | 24 | Eric McClure | Hefty Ford | 49.097 | 183.311 | 11 |
| 4 | 98 | Paul Menard | Menards Ford | 49.119 | 183.228 | 11 |
| 5 | 7 | Danica Patrick | Go Daddy Chevy | 49.161 | 183.072 | 35 |
| 6 | 38 | Kasey Kahne | Great Clips Toyota | 49.173 | 183.027 | 9 |
| 7 | 62 | Brendan Gaughan | South Point Casino & Hotel Toyota | 49.176 | 183.016 | 14 |
| 8 | 22 | Brad Keselowski | Discount Tire Dodge | 49.222 | 182.845 | 16 |
| 9 | 88 | Dale Earnhardt Jr. | Hellmann's Chevy | 49.224 | 182.838 | 12 |
| 10 | 10 | Jason Leffler | ABF U-Pack Moving Toyota | 49.316 | 182.497 | 14 |
| 11 | 40 | Mike Bliss | Key Motorsports Chevy | 49.321 | 182.478 | 16 |
| 12 | 23 | Robert Richardson Jr. | Mahindra Tractors Chevy | 49.323 | 182.471 | 12 |
| 13 | 16 | Colin Braun # | Con-way Freight Ford | 49.332 | 182.437 | 16 |
| 14 | 34 | Tony Raines | Long John Silver's Chevy | 49.366 | 182.312 | 19 |
| 15 | 12 | Justin Allgaier | Verizon Wireless Dodge | 49.375 | 182.278 | 10 |
| 16 | 99 | Trevor Bayne | Diamond Waltrip Racing Toyota | 49.406 | 182.164 | 25 |
| 17 | 70 | Shelby Howard | ForeTravel Motorcoach Chevy | 49.464 | 181.951 | 8 |
| 18 | 27 | Greg Biffle | Redman Moist Snuff Ford | 49.531 | 181.704 | 17 |
| 19 | 05 | Jeff Green | Tobacco Free Florida Chevy | 49.548 | 181.642 | 18 |
| 20 | 87 | Joe Nemechek | DAB Constructors Inc. Chevy | 49.551 | 181.631 | 13 |
| 21 | 66 | Steve Wallace | 5 Hour Energy Toyota | 49.588 | 181.496 | 16 |
| 22 | 33 | Kevin Harvick | Jimmy John's Chevy | 49.705 | 181.068 | 2 |
| 23 | 09 | Scott Riggs | RAB Racing Ford | 49.765 | 180.850 | 13 |
| 24 | 43 | Scott Lagasse Jr. | Baker Curb Racing Ford | 49.858 | 180.513 | 8 |
| 25 | 4 | Tony Stewart | Ritz Crackers Chevy | 49.996 | 180.014 | 2 |
| 26 | 21 | John Wes Townley | Zaxby's Chevy | 50.126 | 179.548 | 2 |
| 27 | 5 | Bobby Gerhart | Lucas Oil Chevy | 50.166 | 179.404 | 15 |
| 28 | 20 | Joey Logano | GameStop Toyota | 50.172 | 179.383 | 2 |
| 29 | 42 | Parker Kligerman # | Team 42 Racing Dodge | 50.191 | 179.315 | 11 |
| 30 | 35 | Jason Keller | TriStar Motorsports Chevy | 50.214 | 179.233 | 12 |
| 31 | 18 | Kyle Busch | Interstate Batteries Toyota | 50.237 | 179.151 | 2 |
| 32 | 96 | Dennis Setzer | K Automotive Dodge | 50.342 | 178.777 | 2 |
| 33 | 6 | Ricky Stenhouse Jr. # | CitiFinancial Ford | 50.361 | 178.710 | 11 |
| 34 | 61 | Josh Wise | Specialty Racing Ford | 50.430 | 178.465 | 9 |
| 35 | 52 | Donnie Neuenberger | IHOP Chevy | 50.473 | 178.313 | 2 |
| 36 | 97 | Jeff Fuller | FrontRowJoe.com Chevy | 50.540 | 178.077 | 7 |
| 37 | 31 | Stanton Barrett | Fuel-doctor.com Chevy | 50.557 | 178.017 | 10 |
| 38 | 11 | Brian Scott | StopRepairBills.com Toyota | 50.599 | 177.869 | 11 |
| 39 | 92 | Johnny Chapman | K Automotive Dodge | 50.624 | 177.781 | 2 |
| 40 | 04 | Brad Teague | SponsorDavis.com Chevy | 50.678 | 177.592 | 1 |
| 41 | 73 | Derrike Cope | AssetProtect / Strutmasterspro.com Dodge | 50.690 | 177.550 | 11 |
| 42 | 26 | Brian Keselowski | K Automotive Dodge | 50.723 | 177.434 | 8 |
| 43 | 49 | Mark Green | Jay Robinson Racing Chevy | 50.748 | 177.347 | 8 |
| 44 | 83 | John Borneman III | Red Line Oil Dodge | 50.793 | 177.190 | 6 |
| 45 | 56 | Kevin Lepage | Revolucion Chevy | 50.860 | 176.956 | 10 |
| 46 | 02 | Danny Efland | CorrisStottRacing.com Chevy | 50.890 | 176.852 | 8 |
| 47 | 0 | Jeremy Clements | Boudreaux's Butt Paste Chevy | 50.915 | 176.765 | 11 |
| 48 | 89 | Morgan Shepherd | Fans For Faith Chevy | 51.087 | 176.170 | 11 |
| 49 | 41 | Chrissy Wallace | Fuel-Doctor.com Chevy | 51.260 | 175.575 | 11 |
| 50 | 75 | Brett Rowe | MtrsprtsRetro/ImperialBedding.com Dodge | 51.664 | 174.203 | 5 |
| 51 | 48 | Johnny Sauter | GetMoreVacations.com Chevy | 52.469 | 171.530 | 4 |
Stewart fastest in opening practice: #4-Tony Stewart, making his only planned start of the year, was the fastest in the opening practice session for the DRIVE4COPD 300 with a speed of 184.695mph. #43-Scott Lagasse was second followed by #40-Mike Bliss, #66-Steve Wallace, #27-Greg Biffle, #1-James Buescher, #22-Brad Keselowski, #88-Dale Earnhardt, Jr., #20-Joey Logano, and #18-Kyle Busch. #7-Danica Patrick was 26th. There was only one caution, for smoke out of the #56 of Kevin Lepage.(2-10-2010)
| Pos | Car | Driver | Team | Time | Speed | # Laps |
| 1 | 4 | Tony Stewart | Ritz Crackers Chevy | 48.729 | 184.695 | 13 |
| 2 | 43 | Scott Lagasse Jr. | Baker Curb Racing Ford | 48.768 | 184.547 | 23 |
| 3 | 40 | Mike Bliss | Key Motorsports Chevy | 48.834 | 184.298 | 23 |
| 4 | 66 | Steve Wallace | 5 Hour Energy Toyota | 48.836 | 184.290 | 20 |
| 5 | 27 | Greg Biffle | Redman Moist Snuff Ford | 48.949 | 183.865 | 15 |
| 6 | 1 | James Buescher # | Phoenix Racing Chevy | 48.983 | 183.737 | 31 |
| 7 | 22 | Brad Keselowski | Discount Tire Dodge | 49.001 | 183.670 | 22 |
| 8 | 88 | Dale Earnhardt Jr. | Hellmann's Chevy | 49.008 | 183.643 | 17 |
| 9 | 20 | Joey Logano | GameStop Toyota | 49.013 | 183.625 | 36 |
| 10 | 18 | Kyle Busch | Interstate Batteries Toyota | 49.019 | 183.602 | 34 |
| 11 | 24 | Eric McClure | Hefty Ford | 49.022 | 183.591 | 19 |
| 12 | 23 | Robert Richardson Jr. | Mahindra Tractors Chevy | 49.027 | 183.572 | 35 |
| 13 | 15 | Michael Annett | Pilot Travel Centers Toyota | 49.030 | 183.561 | 23 |
| 14 | 33 | Kevin Harvick | Jimmy John's Chevy | 49.044 | 183.509 | 23 |
| 15 | 99 | Trevor Bayne | Diamond Waltrip Racing Toyota | 49.053 | 183.475 | 39 |
| 16 | 98 | Paul Menard | Menards Ford | 49.061 | 183.445 | 21 |
| 17 | 32 | Brian Vickers | Dollar General Toyota | 49.073 | 183.400 | 36 |
| 18 | 21 | John Wes Townley | Zaxby's Chevy | 49.086 | 183.352 | 21 |
| 19 | 38 | Kasey Kahne | Great Clips Toyota | 49.102 | 183.292 | 26 |
| 20 | 10 | Jason Leffler | ABF U-Pack Moving Toyota | 49.108 | 183.270 | 27 |
| 21 | 16 | Colin Braun # | Con-way Freight Ford | 49.110 | 183.262 | 27 |
| 22 | 34 | Tony Raines | Long John Silver's Chevy | 49.118 | 183.232 | 40 |
| 23 | 62 | Brendan Gaughan | South Point Casino & Hotel Toyota | 49.123 | 183.214 | 15 |
| 24 | 12 | Justin Allgaier | Verizon Wireless Dodge | 49.136 | 183.165 | 34 |
| 25 | 6 | Ricky Stenhouse Jr. # | CitiFinancial Ford | 49.163 | 183.064 | 28 |
| 26 | 7 | Danica Patrick | Go Daddy Chevy | 49.183 | 182.990 | 38 |
| 27 | 01 | Mike Wallace | Kendrick Meek for Florida Chevy | 49.223 | 182.841 | 22 |
| 28 | 60 | Carl Edwards | Fastenal Ford | 49.283 | 182.619 | 13 |
| 29 | 05 | Jeff Green | Tobacco Free Florida Chevy | 49.316 | 182.497 | 25 |
| 30 | 81 | Michael McDowell | D.H. Griffin Companies Dodge | 49.348 | 182.378 | 15 |
| 31 | 28 | Kenny Wallace | Blue Ox Hitches & Trailers Chevy | 49.408 | 182.157 | 4 |
| 32 | 42 | Parker Kligerman # | Team 42 Racing Dodge | 49.492 | 181.848 | 15 |
| 33 | 5 | Bobby Gerhart | Lucas Oil Chevy | 49.628 | 181.349 | 18 |
| 34 | 11 | Brian Scott | StopRepairBills.com Toyota | 49.818 | 180.658 | 8 |
| 35 | 87 | Joe Nemechek | DAB Constructors Inc. Chevy | 49.828 | 180.621 | 11 |
| 36 | 97 | Jeff Fuller | FrontRowJoe.com Chevy | 50.043 | 179.845 | 2 |
| 37 | 35 | Jason Keller | TriStar Motorsports Chevy | 50.061 | 179.781 | 5 |
| 38 | 70 | Shelby Howard | ForeTravel Motorcoach Chevy | 50.111 | 179.601 | 8 |
| 39 | 09 | Scott Riggs | RAB Racing Ford | 50.292 | 178.955 | 16 |
| 40 | 96 | Dennis Setzer | K Automotive Dodge | 50.354 | 178.735 | 5 |
| 41 | 92 | Johnny Chapman | K Automotive Dodge | 50.479 | 178.292 | 5 |
| 42 | 52 | Donnie Neuenberger | IHOP Chevy | 50.508 | 178.190 | 8 |
| 43 | 49 | Mark Green | Jay Robinson Racing Chevy | 50.636 | 177.739 | 5 |
| 44 | 31 | Stanton Barrett | Fuel-doctor.com Chevy | 50.670 | 177.620 | 8 |
| 45 | 73 | Derrike Cope | AssetProtect / Strutmasterspro.com Dodge | 50.744 | 177.361 | 14 |
| 46 | 0 | Jeremy Clements | Boudreaux's Butt Paste Chevy | 50.831 | 177.057 | 6 |
| 47 | 56 | Kevin Lepage | Revolucion Chevy | 51.073 | 176.218 | 1 |
| 48 | 89 | Morgan Shepherd | Fans For Faith Chevy | 51.101 | 176.122 | 3 |
| 49 | 83 | John Borneman III | Red Line Oil Dodge | 51.115 | 176.074 | 2 |
| 50 | 41 | Chrissy Wallace | Fuel-Doctor.com Chevy | 51.903 | 173.400 | 5 |
| 51 | 75 | Brett Rowe | MotorsportsRetro/ImperialBedding.com Dodge | 51.987 | 173.120 | 2 |
