
Biffle fastest in Happy Hour: #27-Greg Biffle was quickest during the final practice session at Las Vegas with a speed of 182.291mph. He was followed by: #60-Carl Edwards, #99-Trevor Bayne, #11-Brian Scott, #32-Brian Vickers, #18-Kyle Busch, #12-Justin Allgaier, #33-Kevin Harvick, #16-Colin Braun, and #20-Denny Hamlin. #7-Danica Patrick was 25th. There were no incidents.(2-26-2010)
| Pos | Car | Driver | Team | Time | Speed | # Laps |
| 1 | 27 | Greg Biffle | Redman Moist Snuff Ford | 29.623 | 182.291 | 19 |
| 2 | 60 | Carl Edwards | Copart Ford | 29.643 | 182.168 | 27 |
| 3 | 99 | Trevor Bayne | Aaron's Dream Machine Toyota | 29.692 | 181.867 | 25 |
| 4 | 11 | Brian Scott # | StopRepairBills.com Toyota | 29.797 | 181.226 | 27 |
| 5 | 32 | Brian Vickers | Dollar General Toyota | 29.822 | 181.074 | 27 |
| 6 | 18 | Kyle Busch | Z-Line Designs Toyota | 29.879 | 180.729 | 21 |
| 7 | 12 | Justin Allgaier | Verizon Wireless Dodge | 29.901 | 180.596 | 35 |
| 8 | 33 | Kevin Harvick | Rheem Chevy | 29.925 | 180.451 | 28 |
| 9 | 16 | Colin Braun # | Roush Fenway Ford | 29.946 | 180.325 | 49 |
| 10 | 20 | Denny Hamlin | Interstate Batteries Toyota | 30.042 | 179.748 | 22 |
| 11 | 21 | John Wes Townley | Zaxby's Chevy | 30.066 | 179.605 | 16 |
| 12 | 22 | Brad Keselowski | Discount Tire Dodge | 30.075 | 179.551 | 32 |
| 13 | 38 | Jason Leffler | Great Clips Toyota | 30.092 | 179.450 | 33 |
| 14 | 6 | Ricky Stenhouse Jr. # | Roush Fenway Ford | 30.094 | 179.438 | 37 |
| 15 | 43 | Scott Lagasse Jr. | Dr. Gadget / everybodygets1.com Ford | 30.097 | 179.420 | 32 |
| 16 | 15 | Michael Annett | Pilot Travel Centers Toyota | 30.136 | 179.188 | 36 |
| 17 | 88 | Kelly Bires | Hendrickcars.com Chevy | 30.193 | 178.849 | 37 |
| 18 | 1 | James Buescher # | Phoenix Racing Chevy | 30.211 | 178.743 | 24 |
| 19 | 42 | Parker Kligerman # | Smith Ironworks Dodge | 30.361 | 177.860 | 25 |
| 20 | 35 | Jason Keller | Drank Beverage Chevy | 30.367 | 177.825 | 23 |
| 21 | 62 | Brendan Gaughan | South Point Hotel & Casino Toyota | 30.415 | 177.544 | 36 |
| 22 | 90 | Danny O'Quinn Jr. | D'Houdt Humphrey Mtrspts Chevy | 30.431 | 177.451 | 5 |
| 23 | 40 | Mike Bliss | Buck Commander / Bad Boy Buggies Chevy | 30.435 | 177.427 | 25 |
| 24 | 96 | Dennis Setzer | Stratosphere Dodge | 30.438 | 177.410 | 5 |
| 25 | 7 | Danica Patrick | GoDaddy.com Chevy | 30.454 | 177.317 | 52 |
| 26 | 66 | Steve Wallace | 5 Hour Energy Toyota | 30.461 | 177.276 | 29 |
| 27 | 56 | Kevin Lepage | Start Natural Energy Drink Chevy | 30.477 | 177.183 | 10 |
| 28 | 87 | Joe Nemechek | FrontRowJoe.com Chevy | 30.521 | 176.927 | 12 |
| 29 | 01 | Mike Wallace | Monster Diesel Chevy | 30.531 | 176.869 | 20 |
| 30 | 09 | Scott Riggs | RAB Racing Ford | 30.587 | 176.546 | 21 |
| 31 | 70 | Shelby Howard | ForeTravel Motorcoach Chevy | 30.634 | 176.275 | 26 |
| 32 | 49 | Mark Green | Jay Robinson Racing Chevy | 30.655 | 176.154 | 4 |
| 33 | 31 | Stanton Barrett | Fuel-doctor.com Chevy | 30.700 | 175.896 | 16 |
| 34 | 81 | Michael McDowell | Monte Carlo Resort & Casino Dodge | 30.733 | 175.707 | 26 |
| 35 | 73 | Derrike Cope | Asset Protect Dodge | 30.776 | 175.461 | 18 |
| 36 | 07 | Danny Efland | Shred 360 / M&W Towing Chevy | 30.807 | 175.285 | 22 |
| 37 | 92 | Johnny Chapman | K Automotive Motorsports Dodge | 30.814 | 175.245 | 5 |
| 38 | 91 | Stephen Leicht | D'Houdt Humphrey Mtrspts Chevy | 30.911 | 174.695 | 9 |
| 39 | 05 | Willie Allen | 31W Insulation / Certainteed Chevy | 30.948 | 174.486 | 24 |
| 40 | 89 | Morgan Shepherd | Lagina Plumbing Chevy | 31.039 | 173.975 | 23 |
| 41 | 34 | Tony Raines | Planet Hollywood Resort & Casino Chevy | 31.103 | 173.617 | 23 |
| 42 | 61 | Josh Wise | Stratosphere Ford | 31.112 | 173.566 | 15 |
| 43 | 02 | Andy Ponstein | CarLocate.com Chevy | 31.153 | 173.338 | 18 |
| 44 | 26 | Brian Keselowski | Stratosphere Dodge | 31.218 | 172.977 | 19 |
| 45 | 24 | Eric McClure | Hefty Ford | 31.225 | 172.938 | 46 |
| 46 | 28 | Kenny Wallace | Federated Auto Parts Chevy | 31.312 | 172.458 | 2 |
| 47 | 23 | Robert Richardson Jr. | R3 Motorsports Chevy | 31.386 | 172.051 | 38 |
| 48 | 83 | John Borneman III | Twisted X Boots Ford | 31.402 | 171.964 | 10 |
| 49 | 04 | Jeremy Clements | Boudreaux's Butt Paste Chevy | 31.806 | 169.779 | 20 |
Menard fastest in opening practice: #98-Paul Menard was the fastest in the opening practice session for the Sams' Town 300. His top speed was 179.868mph. #27-Greg Biffle was second, followed by #60-Carl Edwards, #18-Kyle Busch, #32-Brian Vickers, #09-Scott Riggs, #38-Jason Leffler, #15-Michael Annett, #16-Colin Braun, and #40-Mike Bliss. #7-Danica Patrick was 23rd. #92-Johnny Chapmam spun coming off turn 2 during the session and hit the inside wall. The team will repair the car.(2-26-2010)
| Pos | Car | Driver | Team | Time | Speed | # Laps |
| 1 | 98 | Paul Menard | Richmond / Menards Ford | 30.022 | 179.868 | 19 |
| 2 | 27 | Greg Biffle | Redman Moist Snuff Ford | 30.115 | 179.313 | 19 |
| 3 | 60 | Carl Edwards | Copart Ford | 30.206 | 178.772 | 16 |
| 4 | 18 | Kyle Busch | Z-Line Designs Toyota | 30.305 | 178.188 | 21 |
| 5 | 32 | Brian Vickers | Dollar General Toyota | 30.313 | 178.141 | 12 |
| 6 | 09 | Scott Riggs | RAB Racing Ford | 30.315 | 178.130 | 24 |
| 7 | 38 | Jason Leffler | Great Clips Toyota | 30.359 | 177.871 | 17 |
| 8 | 15 | Michael Annett | Pilot Travel Centers Toyota | 30.363 | 177.848 | 16 |
| 9 | 16 | Colin Braun # | Roush Fenway Ford | 30.381 | 177.743 | 19 |
| 10 | 40 | Mike Bliss | Buck Commander / Bad Boy Buggies Chevy | 30.395 | 177.661 | 8 |
| 11 | 22 | Brad Keselowski | Discount Tire Dodge | 30.411 | 177.567 | 18 |
| 12 | 11 | Brian Scott # | StopRepairBills.com Toyota | 30.426 | 177.480 | 20 |
| 13 | 88 | Kelly Bires | Hendrickcars.com Chevy | 30.489 | 177.113 | 9 |
| 14 | 20 | Denny Hamlin | Interstate Batteries Toyota | 30.496 | 177.072 | 19 |
| 15 | 66 | Steve Wallace | 5 Hour Energy Toyota | 30.525 | 176.904 | 20 |
| 16 | 87 | Joe Nemechek | FrontRowJoe.com Chevy | 30.532 | 176.864 | 21 |
| 17 | 42 | Parker Kligerman # | Smith Ironworks Dodge | 30.534 | 176.852 | 19 |
| 18 | 33 | Kevin Harvick | Rheem Chevy | 30.573 | 176.626 | 5 |
| 19 | 99 | Trevor Bayne | Aaron's Dream Machine Toyota | 30.607 | 176.430 | 23 |
| 20 | 1 | James Buescher # | Phoenix Racing Chevy | 30.620 | 176.355 | 24 |
| 21 | 6 | Ricky Stenhouse Jr. # | Roush Fenway Ford | 30.649 | 176.188 | 14 |
| 22 | 12 | Justin Allgaier | Verizon Wireless Dodge | 30.651 | 176.177 | 12 |
| 23 | 7 | Danica Patrick | GoDaddy.com Chevy | 30.660 | 176.125 | 37 |
| 24 | 62 | Brendan Gaughan | South Point Hotel & Casino Toyota | 30.669 | 176.074 | 13 |
| 25 | 56 | Kevin Lepage | Start Natural Energy Drink Chevy | 30.671 | 176.062 | 5 |
| 26 | 10 | Chad Blount | Braun Racing Toyota | 30.715 | 175.810 | 11 |
| 27 | 21 | John Wes Townley | Zaxby's Chevy | 30.730 | 175.724 | 19 |
| 28 | 43 | Scott Lagasse Jr. | Dr. Gadget / everybodygets1.com Ford | 30.783 | 175.421 | 16 |
| 29 | 70 | Shelby Howard | ForeTravel Motorcoach Chevy | 30.808 | 175.279 | 12 |
| 30 | 49 | Mark Green | Jay Robinson Racing Chevy | 30.816 | 175.234 | 4 |
| 31 | 01 | Mike Wallace | Monster Diesel Chevy | 30.845 | 175.069 | 12 |
| 32 | 35 | Jason Keller | Drank Beverage Chevy | 30.947 | 174.492 | 13 |
| 33 | 81 | Michael McDowell | Monte Carlo Resort & Casino Dodge | 31.069 | 173.807 | 12 |
| 34 | 31 | Stanton Barrett | Fuel-doctor.com Chevy | 31.137 | 173.427 | 14 |
| 35 | 05 | Willie Allen | 31W Insulation / Certainteed Chevy | 31.259 | 172.750 | 10 |
| 36 | 73 | Derrike Cope | Asset Protect Dodge | 31.342 | 172.293 | 8 |
| 37 | 90 | Danny O'Quinn Jr. | D'Houdt Humphrey Motorsports Chevy | 31.458 | 171.657 | 3 |
| 38 | 02 | Andy Ponstein | CarLocate.com Chevy | 31.511 | 171.369 | 11 |
| 39 | 28 | Kenny Wallace | Federated Auto Parts Chevy | 31.527 | 171.282 | 8 |
| 40 | 83 | John Borneman III | Twisted X Boots Ford | 31.535 | 171.238 | 6 |
| 41 | 34 | Tony Raines | Planet Hollywood Resort & Casino Chevy | 31.545 | 171.184 | 15 |
| 42 | 91 | Stephen Leicht | D'Houdt Humphrey Motorsports Chevy | 31.579 | 171.000 | 6 |
| 43 | 23 | Robert Richardson Jr. | R3 Motorsports Chevy | 31.646 | 170.638 | 18 |
| 44 | 07 | Danny Efland | Shred 360 / M&W Towing Chevy | 31.665 | 170.535 | 10 |
| 45 | 96 | Dennis Setzer | Stratosphere Dodge | 31.702 | 170.336 | 2 |
| 46 | 26 | Brian Keselowski | Stratosphere Dodge | 31.732 | 170.175 | 24 |
| 47 | 24 | Eric McClure | Hefty Ford | 31.827 | 169.667 | 15 |
| 48 | 04 | Jeremy Clements | Boudreaux's Butt Paste Chevy | 31.999 | 168.755 | 11 |
| 49 | 89 | Morgan Shepherd | Lagina Plumbing Chevy | 32.258 | 167.400 | 4 |
| 50 | 61 | Josh Wise | Stratosphere Ford | 32.395 | 166.692 | 4 |
| 51 | 92 | Johnny Chapman | K Automotive Motorsports Dodge | 0.000 | 0.000 | 0 |
