
Scott fastest in Happy Hour: #11-Brian Scott was quickest during the final practice session at Texas with a speed of 184.351mph. He was followed by: #12-Justin Allgaier, #66-Steve Wallace, #60-Carl Edwards, #99-Trevor Bayne, #71-Justin Lofton, #7-Landon Cassill, #22-Brad Keselowski, #40-Mike Bliss & #88-Jamie McMurray. There were no accidents during the session. (4-16-2010)
| Pos | Car | Driver | Team | Time | Speed | # Laps |
| 1 | 11 | Brian Scott # | Dollar General Toyota | 29.292 | 184.351 | 32 |
| 2 | 12 | Justin Allgaier | Verizon Wireless Dodge | 29.302 | 184.288 | 27 |
| 3 | 66 | Steve Wallace | 5-hour Energy Toyota | 29.304 | 184.275 | 37 |
| 4 | 60 | Carl Edwards | Fastenal Ford | 29.317 | 184.193 | 29 |
| 5 | 99 | Trevor Bayne | Diamond-Waltrip Racing Toyota | 29.322 | 184.162 | 31 |
| 6 | 71 | Justin Lofton | WeekendWarriorsTV.com Toyota | 29.325 | 184.143 | 39 |
| 7 | 7 | Landon Cassill | JR Motorsports Chevy | 29.328 | 184.124 | 46 |
| 8 | 22 | Brad Keselowski | Discount Tire Dodge | 29.387 | 183.755 | 33 |
| 9 | 40 | Mike Bliss | Key Motorsports Chevy | 29.402 | 183.661 | 16 |
| 10 | 88 | Jamie McMurray | Hellmann's Chevy | 29.413 | 183.592 | 39 |
| 11 | 21 | Clint Bowyer | Zaxby's Chevy | 29.430 | 183.486 | 30 |
| 12 | 43 | Scott Lagasse Jr. | Autism Awareness/O'Reilly Auto Parts Ford | 29.431 | 183.480 | 21 |
| 13 | 6 | Ricky Stenhouse Jr. # | CitiFinancial Ford | 29.444 | 183.399 | 34 |
| 14 | 16 | Colin Braun # | Con-way Freight Ford | 29.476 | 183.200 | 43 |
| 15 | 1 | James Buescher # | Phoenix Racing Chevy | 29.487 | 183.132 | 47 |
| 16 | 18 | Kyle Busch | Z-Line Designs Toyota | 29.488 | 183.125 | 26 |
| 17 | 32 | Reed Sorenson | Dollar General Stores Toyota | 29.497 | 183.069 | 28 |
| 18 | 38 | Jason Leffler | Great Clips Toyota | 29.542 | 182.791 | 33 |
| 19 | 09 | Chad McCumbee | TheGPSStore.com Ford | 29.621 | 182.303 | 25 |
| 20 | 90 | Danny O'Quinn Jr. | D'Hondt Humphrey Mtrspts Chevy | 29.625 | 182.278 | 3 |
| 21 | 33 | Kevin Harvick | Rheem Tankless Chevy | 29.632 | 182.235 | 27 |
| 22 | 98 | Paul Menard | Richmond/Menards Ford | 29.639 | 182.192 | 34 |
| 23 | 92 | Dennis Setzer | K-Automotive Motorsports Dodge | 29.676 | 181.965 | 4 |
| 24 | 20 | Joey Logano | GameStop/Red Dead Redemption Toyota | 29.689 | 181.886 | 33 |
| 25 | 91 | David Gilliland | D'Hondt Humphrey Mtrspts Chevy | 29.690 | 181.879 | 5 |
| 26 | 10 | David Reutimann | Beringer Vineyards Toyota | 29.713 | 181.739 | 32 |
| 27 | 27 | Greg Biffle | Red Man Moist Snuff Ford | 29.750 | 181.513 | 34 |
| 28 | 15 | Michael Annett | Pilot Travel Centers Toyota | 29.797 | 181.226 | 38 |
| 29 | 70 | Shelby Howard | ForeTravel Chevy | 29.800 | 181.208 | 27 |
| 30 | 34 | Tony Raines | Long John Silver's Chevy | 29.820 | 181.087 | 29 |
| 31 | 87 | Joe Nemechek | NEMCO Motorsports Chevy | 29.844 | 180.941 | 23 |
| 32 | 35 | Jason Keller | Tri Star Motorsports Chevy | 29.863 | 180.826 | 9 |
| 33 | 62 | Brendan Gaughan | Loan Star Title Loans Toyota | 29.879 | 180.729 | 25 |
| 34 | 56 | Kevin Lepage | Cattlemen's Steakhouse/Courtyard Marriott | 29.920 | 180.481 | 7 |
| 35 | 05 | David Starr | 31-W Insulation Chevy | 30.004 | 179.976 | 25 |
| 36 | 49 | Mark Green | Jay Robinson Racing Chevy | 30.037 | 179.778 | 5 |
| 37 | 04 | Jeremy Clements | Boudreaux's Butt Paste Chevy | 30.037 | 179.778 | 8 |
| 38 | 61 | Josh Wise | Elliottbrand Web Designs Ford | 30.137 | 179.182 | 17 |
| 39 | 89 | Morgan Shepherd | DealTaker.com Chevy | 30.268 | 178.406 | 10 |
| 40 | 81 | Michael McDowell | iamsecond.com Dodge | 30.350 | 177.924 | 24 |
| 41 | 23 | Robert Richardson Jr. | R3 Motorsports Chevy | 30.366 | 177.830 | 35 |
| 42 | 73 | Derrike Cope | Dean Guitar/Charter Dodge | 30.419 | 177.521 | 11 |
| 43 | 07 | Danny Efland | Danny Efland Racing Chevy | 30.448 | 177.352 | 9 |
| 44 | 01 | Mike Wallace | jdavismotorsports.com Chevy | 30.527 | 176.893 | 24 |
| 45 | 24 | Eric McClure | Hefty Ford | 30.715 | 175.810 | 20 |
| 46 | 26 | B. Keselowski / D. | Stubb's BBQ Dodge | 30.748 | 175.621 | 18 |
| 47 | 28 | Kenny Wallace | Chloe Duyck Memorial Fund Chevy | 0.000 | 0.000 | 0 |
Allgaier fastest in opening practice: #12-Justin Allgaier was the fastest in the opening practice session for the O'Reilly Auto Parts 300. His top speed 185.656mph. #27-Greg Biffle was second followed by: #6-Ricky Stenhouse, #11-Brian Scott, #18-Kyle Busch, #33-Kevin Harvick, #40-Mike Bliss, #22-Brad Keselowski, #98-Paul Menard, and #7-Landon Cassill. Cassill also practice the #88 for Jamie McMurray who was not at the track.(4-15-2010)
| Pos | Car | Driver | Team | Time | Speed | # Laps |
| 1 | 12 | Justin Allgaier | Verizon Wireless Dodge | 29.086 | 185.656 | 13 |
| 2 | 27 | Greg Biffle | Red Man Moist Snuff Ford | 29.142 | 185.300 | 18 |
| 3 | 6 | Ricky Stenhouse Jr. # | CitiFinancial Ford | 29.145 | 185.280 | 18 |
| 4 | 11 | Brian Scott # | Dollar General Toyota | 29.214 | 184.843 | 19 |
| 5 | 18 | Kyle Busch | Z-Line Designs Toyota | 29.260 | 184.552 | 9 |
| 6 | 33 | Kevin Harvick | Rheem Tankless Chevy | 29.384 | 183.773 | 4 |
| 7 | 40 | Mike Bliss | Key Motorsports Chevy | 29.454 | 183.337 | 19 |
| 8 | 22 | Brad Keselowski | Discount Tire Dodge | 29.481 | 183.169 | 8 |
| 9 | 98 | Paul Menard | Richmond/Menards Ford | 29.518 | 182.939 | 18 |
| 10 | 7 | Landon Cassill | JR Motorsports Chevy | 29.525 | 182.896 | 32 |
| 11 | 38 | Jason Leffler | Great Clips Toyota | 29.542 | 182.791 | 14 |
| 12 | 60 | Carl Edwards | Fastenal Ford | 29.591 | 182.488 | 16 |
| 13 | 10 | David Reutimann | Beringer Vineyards Toyota | 29.608 | 182.383 | 9 |
| 14 | 21 | Clint Bowyer | Zaxby's Chevy | 29.610 | 182.371 | 5 |
| 15 | 20 | Joey Logano | GameStop/Red Dead Redemption Toyota | 29.644 | 182.162 | 12 |
| 16 | 66 | Steve Wallace | 5-hour Energy Toyota | 29.676 | 181.965 | 13 |
| 17 | 92 | Dennis Setzer | K-Automotive Motorsports Dodge | 29.676 | 181.965 | 2 |
| 18 | 15 | Michael Annett | Pilot Travel Centers Toyota | 29.691 | 181.873 | 18 |
| 19 | 71 | Justin Lofton | WeekendWarriorsTV.com Toyota | 29.708 | 181.769 | 24 |
| 20 | 49 | Mark Green | Jay Robinson Racing Chevy | 29.723 | 181.677 | 2 |
| 21 | 16 | Colin Braun # | Con-way Freight Ford | 29.742 | 181.561 | 26 |
| 22 | 32 | Reed Sorenson | Dollar General Stores Toyota | 29.756 | 181.476 | 20 |
| 23 | 1 | James Buescher # | Phoenix Racing Chevy | 29.820 | 181.087 | 38 |
| 24 | 09 | Chad McCumbee | TheGPSStore.com Ford | 29.824 | 181.062 | 23 |
| 25 | 56 | Kevin Lepage | Cattlemen's Steakhouse/Courtyard Marriott | 29.858 | 180.856 | 7 |
| 26 | 90 | Danny O'Quinn Jr. | D'Hondt Humphrey Mtrspts Chevy | 29.899 | 180.608 | 2 |
| 27 | 62 | Brendan Gaughan | Loan Star Title Loans Toyota | 29.951 | 180.294 | 12 |
| 28 | 87 | Joe Nemechek | NEMCO Motorsports Chevy | 29.967 | 180.198 | 19 |
| 29 | 34 | Tony Raines | Long John Silver's Chevy | 30.019 | 179.886 | 16 |
| 30 | 05 | David Starr | 31-W Insulation Chevy | 30.027 | 179.838 | 13 |
| 31 | 43 | Scott Lagasse Jr. | Autism Awareness/O'Reilly Auto Parts Ford | 30.045 | 179.730 | 17 |
| 32 | 99 | Trevor Bayne | Diamond-Waltrip Racing Toyota | 30.181 | 178.921 | 16 |
| 33 | 35 | Jason Keller | Tri Star Motorsports Chevy | 30.216 | 178.713 | 20 |
| 34 | 28 | Kenny Wallace | Chloe Duyck Memorial Fund Chevy | 30.265 | 178.424 | 2 |
| 35 | 70 | Shelby Howard | ForeTravel Chevy | 30.282 | 178.324 | 6 |
| 36 | 01 | Mike Wallace | jdavismotorsports.com Chevy | 30.331 | 178.036 | 6 |
| 37 | 61 | Josh Wise | Elliottbrand Web Designs Ford | 30.373 | 177.789 | 17 |
| 38 | 26 | Brian Keselowski | Stubb's BBQ Dodge | 30.470 | 177.223 | 25 |
| 39 | 07 | Danny Efland | Danny Efland Racing Chevy | 30.471 | 177.218 | 14 |
| 40 | 04 | Jeremy Clements | Boudreaux's Butt Paste Chevy | 30.473 | 177.206 | 17 |
| 41 | 89 | Morgan Shepherd | DealTaker.com Chevy | 30.513 | 176.974 | 12 |
| 42 | 24 | Eric McClure | Hefty Ford | 30.528 | 176.887 | 9 |
| 43 | 23 | Robert Richardson Jr. | R3 Motorsports Chevy | 30.753 | 175.593 | 24 |
| 44 | 81 | Michael McDowell | iamsecond.com Dodge | 30.755 | 175.581 | 10 |
| 45 | 88 | Landon Cassill | Hellmann's Chevy | 30.860 | 174.984 | 4 |
| 46 | 73 | Derrike Cope | Dean Guitar/Charter Dodge | 31.211 | 173.016 | 3 |
