
Edwards fastest in practice: #60-Carl Edwards was the fastest in the only practice session for the Royal Purple 200 at Darlington. His top speed was 173.755mph. #10-Jason Leffler was second. The rest of the top 10: #38-Kasey Kahne, #22-Brad Keselowski, #91-David Gilliland, #21-Clint Bowyer, #18-Kyle Busch, #32-Brian Vickers, #20-Denny Hamlin, and #1-James Buescher. Several drivers made contact with the Darlington wall during the session, including #66-Steve Wallace, #27-Greg Biffle, #15-Michael Annett, #41-Stanton Barrett, and #40-Mike Bliss.(5-7-2010)
| Pos | Car | Driver | Team | Time | Speed | # Laps |
| 1 | 60 | Carl Edwards | Copart Ford | 28.302 | 173.755 | 55 |
| 2 | 10 | Jason Leffler | ABF Freight Toyota | 28.304 | 173.742 | 40 |
| 3 | 38 | Kasey Kahne | Great Clips Toyota | 28.353 | 173.442 | 64 |
| 4 | 22 | Brad Keselowski | Ruby Tuesday Dodge | 28.437 | 172.930 | 79 |
| 5 | 91 | David Gilliland | D'Hondt Humphrey Motorsports Chevy | 28.445 | 172.881 | 7 |
| 6 | 21 | Clint Bowyer | Zaxby's Chevy | 28.445 | 172.881 | 45 |
| 7 | 18 | Kyle Busch | Z-Line Designs / Racing for Kids Toyota | 28.507 | 172.505 | 79 |
| 8 | 32 | Brian Vickers | Dollar General Toyota | 28.535 | 172.336 | 46 |
| 9 | 20 | Denny Hamlin | Z-Line Designs / Operation Helmet Toyota | 28.550 | 172.245 | 56 |
| 10 | 1 | James Buescher # | AndreBauer.com / Andre for Governor Chevy | 28.559 | 172.191 | 62 |
| 11 | 33 | Kevin Harvick | Rheem Ruud Chevy | 28.569 | 172.131 | 56 |
| 12 | 11 | Brian Scott # | AccuDoc Solutions Toyota | 28.588 | 172.016 | 40 |
| 13 | 98 | Paul Menard | Richmond / Menards Ford | 28.598 | 171.956 | 46 |
| 14 | 90 | Danny O'Quinn Jr. | D'Hondt Humphrey Motorsports Chevy | 28.622 | 171.812 | 9 |
| 15 | 16 | Matt Kenseth | Coupons.com Ford | 28.640 | 171.704 | 53 |
| 16 | 6 | Ricky Stenhouse Jr. # | Roush Fenway Racing Ford | 28.684 | 171.441 | 66 |
| 17 | 81 | Michael McDowell | MOBILE-Shop.com Dodge | 28.693 | 171.387 | 43 |
| 18 | 99 | Trevor Bayne | Diamond-Waltrip Racing Toyota | 28.714 | 171.261 | 73 |
| 19 | 12 | Justin Allgaier | Verizon Wireless Dodge | 28.722 | 171.214 | 40 |
| 20 | 88 | Jamie McMurray | Hellmann's Chevy | 28.782 | 170.857 | 48 |
| 21 | 66 | Steve Wallace | 5-Hour Energy Toyota | 28.798 | 170.762 | 46 |
| 22 | 27 | Greg Biffle | Redman Moist Snuff Ford | 28.799 | 170.756 | 29 |
| 23 | 40 | Mike Bliss | Westerman Companies Chevy | 28.854 | 170.430 | 34 |
| 24 | 35 | Jason Keller | upillar.com Chevy | 28.911 | 170.094 | 49 |
| 25 | 23 | Coleman Pressley | R3 Motorsports Chevy | 28.942 | 169.912 | 90 |
| 26 | 43 | Scott Lagasse Jr. | American Red Cross / O'Reilly Auto Parts Ford | 28.949 | 169.871 | 56 |
| 27 | 15 | Michael Annett | Germain.com / Pilot Travel Centers Toyota | 29.003 | 169.555 | 48 |
| 28 | 09 | Chad McCumbee | TheGPSStore.com / Garmin Ford | 29.017 | 169.473 | 46 |
| 29 | 62 | Brendan Gaughan | South Point Casino & Hotel Toyota | 29.084 | 169.083 | 46 |
| 30 | 73 | Derrike Cope | Charter Dodge | 29.104 | 168.966 | 14 |
| 31 | 34 | Tony Raines | Long John Silver's Chevy | 29.157 | 168.659 | 52 |
| 32 | 89 | Morgan Shepherd | Racing with Jesus Chevy | 29.200 | 168.411 | 22 |
| 33 | 7 | Steve Arpin | JR Motorsports Chevy | 29.224 | 168.273 | 82 |
| 34 | 41 | Stanton Barrett | Kids Embrace Car Seats Chevy | 29.247 | 168.140 | 39 |
| 35 | 24 | Eric McClure | Hefty Odor Block Ford | 29.257 | 168.083 | 58 |
| 36 | 92 | Dennis Setzer | K-Automotive Motorsports Dodge | 29.280 | 167.951 | 16 |
| 37 | 87 | Joe Nemechek | NEMCO Motorsports Chevy | 29.291 | 167.888 | 41 |
| 38 | 07 | Danny Efland | C3i Sports/AmrcnsHnrngAmericans Chevy | 29.350 | 167.550 | 40 |
| 39 | 70 | Mark Green | Royal Purple Chevy | 29.402 | 167.254 | 6 |
| 40 | 26 | Brian Keselowski | K-Automotive Motorsports Dodge | 29.528 | 166.540 | 25 |
| 41 | 96 | Johnny Chapman | K-Automotive Motorsports Dodge | 29.536 | 166.495 | 12 |
| 42 | 28 | Kenny Wallace | Royal Purple / AAA Parking Chevy | 29.572 | 166.292 | 21 |
| 43 | 56 | Kevin Lepage | Mac Hill Motorsports Chevy | 29.602 | 166.124 | 12 |
| 44 | 01 | Mike Wallace | One Hour Air Conditioning & Heating Chevy | 29.607 | 166.096 | 18 |
| 45 | 05 | Willie Allen | 31W Insulation Chevy | 29.622 | 166.012 | 27 |
| 46 | 61 | Josh Wise | Ride to the Rock for Autism Ford | 29.652 | 165.844 | 30 |
