
Dibenedetto fastest in practice: #20-Matt Dibenedetto was the fastest in the only practice session for the U.S. Cellular 250. His top speed was 132.247mph. #66-Steve Wallace was second, followed by #11-Brian Scott, #38-Jason Leffler, #27-Drew Herring, #56-Kevin Lepage, #99-Trevor Bayne, #91-Chase Miller, #70-Shelby Howard, and #88-Steve Arpin.(7-30-2010)
| Pos | Car | Driver | Team | Time | Speed | # Laps |
| 1 | 20 | Matt DiBenedetto | Pizza Ranch Toyota | 23.819 | 132.247 | 33 |
| 2 | 66 | Steve Wallace | 5-hour Energy Toyota | 23.860 | 132.020 | 41 |
| 3 | 11 | Brian Scott # | AccuDoc Toyota | 23.903 | 131.783 | 32 |
| 4 | 38 | Jason Leffler | Great Clips Toyota | 23.915 | 131.716 | 33 |
| 5 | 27 | Drew Herring | Baker Curb Racing Ford | 23.936 | 131.601 | 35 |
| 6 | 56 | Kevin Lepage | RaceDaySponsor.com Toyota | 23.937 | 131.595 | 8 |
| 7 | 99 | Trevor Bayne | Aaron's Dream Machine Toyota | 23.961 | 131.464 | 35 |
| 8 | 91 | Chase Miller | D'Hondt-Humphrey Motorsports Chevy | 23.963 | 131.453 | 7 |
| 9 | 70 | Shelby Howard | InternationalTrucks.com Chevy | 23.984 | 131.338 | 28 |
| 10 | 88 | Steve Arpin | RealTree Outfitters Chevy | 24.041 | 131.026 | 41 |
| 11 | 90 | Danny O'Quinn Jr. | D'Hondt-Humphrey Motorsports Chevy | 24.057 | 130.939 | 5 |
| 12 | 62 | Brendan Gaughan | South Point Hotel & Casino Toyota | 24.061 | 130.917 | 37 |
| 13 | 6 | Ricky Stenhouse Jr. # | Citifinancial Ford | 24.097 | 130.722 | 30 |
| 14 | 40 | Mike Bliss | Westerman Companies/Courtyard Marriott | 24.111 | 130.646 | 38 |
| 15 | 10 | Tayler Malsam | Iron Horse Jeans Toyota | 24.135 | 130.516 | 37 |
| 16 | 26 | Brian Keselowski | K-Automotive Motorsports Dodge | 24.166 | 130.348 | 13 |
| 17 | 33 | David Mayhew | Jimmy John's Chevy | 24.169 | 130.332 | 36 |
| 18 | 15 | Michael Annett | Northland Oil Toyota | 24.185 | 130.246 | 32 |
| 19 | 35 | Jason Keller | TriStar Motorsports Chevy | 24.185 | 130.246 | 37 |
| 20 | 49 | Mark Green | Blue Ox Chevy | 24.192 | 130.208 | 8 |
| 21 | 12 | Justin Allgaier | Verizon Wireless Dodge | 24.204 | 130.144 | 21 |
| 22 | 32 | Jason Leffler | Dollar General Stores Toyota | 24.207 | 130.128 | 4 |
| 23 | 60 | Erik Darnell | Fastenal Ford | 24.239 | 129.956 | 31 |
| 24 | 22 | Parker Kligerman | Discount Tire Dodge | 24.249 | 129.902 | 47 |
| 25 | 09 | John Wes Townley | Zaxby's Ford | 24.276 | 129.758 | 33 |
| 26 | 18 | Brad Coleman | Z-Line Designs Toyota | 24.295 | 129.656 | 42 |
| 27 | 36 | Jeff Green | Long John Silver's Chevy | 24.297 | 129.646 | 14 |
| 28 | 89 | Johnny Chapman | Victory In Jesus Racing Chevy | 24.318 | 129.534 | 11 |
| 29 | 7 | Josh Wise | GoDaddy-HowDoYou?.com Chevy | 24.319 | 129.528 | 50 |
| 30 | 05 | Blake Koch | Daystar/31-W Insulation Chevy | 24.335 | 129.443 | 30 |
| 31 | 34 | Tony Raines | Long John Silver's Chevy | 24.341 | 129.411 | 32 |
| 32 | 92 | Dennis Setzer | K-Automotive Motorsports Dodge | 24.349 | 129.369 | 13 |
| 33 | 98 | Brian Ickler | Mastercraft/Menards Ford | 24.366 | 129.279 | 30 |
| 34 | 24 | Eric McClure | Hefty Odor Block Ford | 24.378 | 129.215 | 19 |
| 35 | 21 | Morgan Shepherd | Victory In Jesus Chevy | 24.385 | 129.178 | 37 |
| 36 | 81 | Matt Carter | K-Love Dodge | 24.419 | 128.998 | 30 |
| 37 | 16 | Colin Braun # | 3M Ford | 24.431 | 128.935 | 39 |
| 38 | 02 | Daryl Harr | WestWorld Computers Chevy | 24.450 | 128.834 | 42 |
| 39 | 04 | Jeremy Clements | Boudreaux's Butt Paste Chevy | 24.460 | 128.782 | 25 |
| 40 | 28 | Kenny Wallace | Cookie's BBQ Chevy | 24.507 | 128.535 | 18 |
| 41 | 83 | John Borneman | Red Line Oil/Twisted X Boots Ford | 24.560 | 128.257 | 23 |
| 42 | 01 | Mike Wallace | Hy-Vee Chevy | 24.621 | 127.940 | 21 |
| 43 | 43 | Brad Baker | Pinnacle Truck & Trailer Sales Ford | 24.698 | 127.541 | 6 |
| 44 | 52 | Tim Schendel | Cobblestone Inn & Suites/My 3 Sons Vending | 24.763 | 127.206 | 26 |
| 45 | 23 | R. Richardson Jr. / M. | R3 Motorsports Chevy | 24.860 | 126.710 | 43 |
| 46 | 87 | Dennis Setzer | HostGator Chevy | 24.918 | 126.415 | 5 |
